Medical Disclaimer

This website is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, changing, or stopping any medication or supplement. Dosage information reflects published FDA-approved labeling or publicly available clinical trial data — individual treatment decisions must be made by a licensed physician.

About Growth Hormone Releasing Peptides (Sermorelin, Ipamorelin, CJC-1295)

Growth hormone secretagogue peptides (sermorelin, ipamorelin, CJC-1295) stimulate the pituitary to produce more growth hormone. Sermorelin is the only FDA-approved peptide in this class; ipamorelin and CJC-1295 are research compounds. Dosing is highly variable and provider-dependent.

Indication

Growth hormone deficiency (sermorelin, FDA-approved). Ipamorelin and CJC-1295 are not FDA-approved. Research/wellness use only.

Research / Trial Dosing Reference

Dosing data from published clinical trials. Not an approved prescription protocol.

Week / PhaseDoseAt 2.5 mg/mLAt 5 mg/mLNotes
Sermorelin starting200 mcg10 units
(2 mg/mL)
4 units
(5 mg/mL)
Common starting dose for sermorelin therapy. Administered at bedtime.
Sermorelin maintenance300 mcg15 units
(2 mg/mL)
6 units
(5 mg/mL)
Common maintenance dose.
Ipamorelin standard200 mcg10 units
(2 mg/mL)
4 units
(5 mg/mL)
Common research dose for ipamorelin. Not FDA-approved.
CJC-1295 (with DAC) standard1–2 mg75 units
(2 mg/mL)
30 units
(5 mg/mL)
CJC-1295 with DAC has a longer half-life — often dosed 1–2x per week. Not FDA-approved.

Units shown assume a standard U-100 insulin syringe (100 units = 1 mL). Always confirm your vial concentration with your pharmacy.

Dose Calculator

Enter your prescribed dose and vial concentration to calculate how many units to draw.

mg ↔ Units Dose Calculator

Convert between milligrams and insulin-syringe units for compounded GLP-1 medications. Uses a standard U-100 syringe (100 units = 1 mL).

Units (U-100 syringe)100 units
Volume1.000 mL

2.5 mg at 2.5 mg/mL → 1.000 mL → 100 units on a U-100 (100-unit / 1 mL) insulin syringe

Always verify calculations with your prescribing provider or pharmacist before administering any medication. This calculator is for reference only.

Injection Sites

Subcutaneous (abdomen or thigh)

SubQ injection before bedtime into abdominal or thigh fat.

  • Bedtime injection aligns with natural GH secretion pattern
  • Rotate sites to prevent local reactions
  • Use 29–31 gauge insulin syringe
  • Fast for 2–3 hours before injection (food blunts GH response)

Storage Instructions

  • Lyophilized (freeze-dried) peptide: store frozen or refrigerated
  • After reconstitution with bacteriostatic water: refrigerate, use within 30 days
  • Protect from light
  • Do not shake — gently swirl to mix

Common Side Effects

Contact your healthcare provider if side effects are severe or persistent.

  • Water retention (bloating)
  • Joint stiffness
  • Numbness or tingling (carpal tunnel-like symptoms)
  • Injection site redness
  • Increased hunger
  • Vivid dreams (related to GH increase)

Frequently Asked Questions

Q

What is the difference between sermorelin and ipamorelin?

Sermorelin is a synthetic version of GHRH (Growth Hormone Releasing Hormone) — it signals the pituitary to release GH naturally. Ipamorelin is a GHRP (Growth Hormone Releasing Peptide) that works through a different receptor (ghrelin receptor). Sermorelin is FDA-approved; ipamorelin is not. They are sometimes combined for a synergistic effect.
Q

Is CJC-1295 the same as sermorelin?

No. Both are GHRH analogues, but CJC-1295 (especially with DAC) has a much longer half-life — lasting days rather than minutes. This allows weekly instead of daily dosing. CJC-1295 is not FDA-approved.
Q

Why take HGH peptides before bed?

Natural GH is secreted in pulses, with the largest pulse occurring during deep sleep (slow-wave sleep). Injecting GHRH/GHRP peptides before sleep amplifies this natural pulse rather than creating a sustained non-pulsatile GH elevation (as with synthetic HGH injections).

Primary Source

FDA / Clinical Source

Dosing information sourced from: https://www.accessdata.fda.gov/drugsatfda_docs/label/1996/020408lbl.pdf